BioResearchAgent

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Task A1 · direct factual retrieval

According to the corpus, what kind of protein does the TP53 gene encode and what is its canonical function?

Acceptable answer concepts

  • p53
  • tumor suppressor
  • growth-inhibitory function

Construction note

Answer concepts taken verbatim from the abstracts' own descriptions of TP53/p53 ("tumor suppressor gene TP53", "canonical tumor suppressor functions").

How each architecture answered

Baseline 0 · no retrieval

Yuu no Sekai · 535 tokens · 4.1s

The TP53 gene encodes a tumor suppressor protein that plays a critical role in genome stability and cellular stress responses.

factualrejectedconf 1.00

The TP53 gene encodes a protein.

factualrejectedconf 1.00

The protein encoded by the TP53 gene is a tumor suppressor.

factualrejectedconf 1.00

The canonical function of the TP53 protein is to maintain genome stability and respond to cellular stress.

run_failed: 0claim_support_rate: 0%unsupported_claim_rate: 100%abstention_correct: 100%concept_coverage: 33%

Baseline 1 · retrieve + synthesize

Yuu no Sekai · 2460 tokens · 4.6s
query(ies): According to the corpus, what kind of protein does the TP53 gene encode and what is its canonical function?

The TP53 gene encodes the tumor suppressor protein p53, which has a canonical function as a tumor suppressor.

factualverifiedconf 1.00

The TP53 gene encodes the tumor suppressor protein p53.

PMID:42701099Direct supportPMID:31897170Direct supportPMID:42700791Direct support
factualverifiedconf 1.00

The canonical function of the p53 protein is as a tumor suppressor.

PMID:42701099Direct supportPMID:31897170Direct supportPMID:42700791Direct support
run_failed: 0retrieval_recall_at_k: 100%retrieval_mrr: 50%claim_support_rate: 100%unsupported_claim_rate: 0%citation_precision: 100%source_validity_rate: 100%abstention_correct: 100%concept_coverage: 67%

Agent 1 · planner + retrieve + synthesize

Yuu no Sekai · 2184 tokens · 6.5s
query(ies): TP53 gene encoded protein | TP53 gene canonical function
planner → {"queries": ["TP53 gene encoded protein", "TP53 gene canonical function"]}

The TP53 gene encodes the tumor suppressor protein p53, which has a canonical function in preventing cancer by regulating cell cycle arrest, DNA repair, and apoptosis.

factualverifiedconf 1.00

The TP53 gene encodes the p53 protein.

PMID:42701099Direct supportPMID:31897170Direct supportPMID:31792264Direct support
factualverifiedconf 1.00

The p53 protein functions as a tumor suppressor.

PMID:42701099Direct supportPMID:31897170Direct supportPMID:31792264Direct support
run_failed: 0retrieval_recall_at_k: 50%retrieval_mrr: 100%claim_support_rate: 100%unsupported_claim_rate: 0%citation_precision: 100%source_validity_rate: 100%abstention_correct: 100%concept_coverage: 67%