Task E1 · multi hop synthesis
Via what intermediate binding partner does BRCA1 reach downstream DNA-repair effector proteins, according to the corpus, and which effectors are named?
Gold evidence
Acceptable answer concepts
- BARD1 is BRCA1's obligate binding partner
- BARD1's intrinsically disordered region engages RAD51, BLM, and WRN
Construction note
Requires chaining two facts from the same abstract (BRCA1-BARD1 heterodimer; BARD1-RAD51/BLM/WRN engagement) rather than a single lookup -- a minimal within-document multi-hop case for v0.
How each architecture answered
Baseline 0 · no retrieval
Yuu no Sekai · 464 tokens · 4.2s(abstained) No evidence passages were retrieved for this question, so the specific intermediate binding partner of BRCA1 and the named downstream DNA-repair effector proteins could not be identified.
The specific intermediate binding partner of BRCA1 and downstream DNA-repair effector proteins could not be identified due to lack of evidence.
Baseline 1 · retrieve + synthesize
Yuu no Sekai · 2272 tokens · 7.8sBRCA1 reaches downstream DNA-repair effector proteins via the intermediate binding partner BARD1. The named effectors are RAD51, BLM, WRN, RAD50, MYC, and RB.
BRCA1 reaches downstream DNA-repair effector proteins via BARD1 as an intermediate binding partner.
The DNA-repair effector proteins named in the corpus include RAD51, BLM, WRN, RAD50, MYC, and RB.
Agent 1 · planner + retrieve + synthesize
Yuu no Sekai · 2445 tokens · 6.1sBRCA1 reaches downstream DNA-repair effector proteins via the intermediate binding partner BARD1. The named effectors are RAD51, BLM, and WRN.
BARD1 is the intermediate binding partner of BRCA1 that facilitates its interaction with downstream DNA-repair effector proteins.
The DNA-repair effector proteins named in the passage include RAD51, BLM, and WRN.